Analysis performed on 2024-07-10 11:39:55
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 48220 | 4310 | 43910 | 26233 |
| Archaea | 3853 | 468 | 3385 | 1384 |
| Vertebrata | 1491 | 656 | 835 | 429 |
| Mammals | 471 | 54 | 417 | 133 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 900 | 54 | 772 |
| Domains | |
|---|---|
| Current Study | 1, 256 |
| Guo et al (2010) | 8, 218 | 844, 897 |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 645 | 255 | 900 | 2.529412 |
| Number of Variants | 568 | 258 | 826 | 2.201550 |
| Number of Pathogenic Variants | 46 | 8 | 54 | 5.750000 |
| Number of Benign/Unknown Variants | 522 | 250 | 772 | 2.088000 |
| Fisher exact test | 0.006028 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 635 | 265 | 900 | 2.396226 |
| Number of Variants | 552 | 274 | 826 | 2.014599 |
| Number of Pathogenic Variants | 43 | 11 | 54 | 3.909091 |
| Number of Benign/Unknown Variants | 509 | 263 | 772 | 1.935361 |
| Fisher exact test | 0.050832 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 645 | 255 | 0.74 (0.01) | 0.69 (0.01) | 7.352e-01 | 6.919e-01 | 94172.50 | 3.42e-04 |
| Guo et al (2010) | 635 | 265 | 0.73 (0.01) | 0.70 (0.01) | 7.337e-01 | 6.959e-01 | 94154.50 | 2.42e-03 |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.